Biology:Cyclic AMP receptors

From HandWiki
Short description: Family of G-protein coupled receptors
Slime mold cyclic AMP receptor
Identifiers
SymbolDicty_CAR
PfamPF05462
Pfam clanCL0192
InterProIPR000848
PROSITEPDOC00691
CDDcd14940

Cyclic AMP receptors from slime molds are a distinct family of G-protein coupled receptors. These receptors control development in Dictyostelium discoideum.

In D. discoideum, the cyclic AMP receptors coordinate aggregation of individual cells into a multicellular organism, and regulate the expression of a large number of developmentally-regulated genes.[1][2][3] The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains, in a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However, while a similar 3D framework has been proposed to account for this, there is no significant sequence similarity between these families: the cAMP receptors thus bear their own unique '7TM' signature.

See also

  • cAMP receptor protein

References

  1. "A chemoattractant receptor controls development in Dictyostelium discoideum". Science 241 (4872): 1467–1472. 1988. doi:10.1126/science.3047871. PMID 3047871. Bibcode1988Sci...241.1467K. 
  2. "CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum". Genes Dev. 7 (2): 262–272. 1993. doi:10.1101/gad.7.2.262. PMID 8436297. 
  3. "Identification and targeted gene disruption of cAR3, a cAMP receptor subtype expressed during multicellular stages of Dictyostelium development". Genes Dev. 7 (2): 273–282. 1993. doi:10.1101/gad.7.2.273. PMID 8382181.