Biology:Condensation domain

From HandWiki
Condensation
PDB 1l5a EBI.jpg
crystal structure of vibh, an nrps condensation enzyme
Identifiers
SymbolCondensation
PfamPF00668
Pfam clanCL0149
InterProIPR001242
SCOP21l5a / SCOPe / SUPFAM

In molecular biology, the condensation domain is a protein domain found in many multi-domain enzymes which synthesise peptide antibiotics. This domain catalyses a condensation reaction to form peptide bonds in non-ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pp-binding). It has been shown that mutations in the HHXXXDG sequence motif in this domain abolish activity suggesting this is part of the active site.[1]

References

  1. "Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain". J. Biol. Chem. 273 (35): 22773–81. August 1998. doi:10.1074/jbc.273.35.22773. PMID 9712910. 
This article incorporates text from the public domain Pfam and InterPro: IPR001242