Biology:Caspase-10
From HandWiki
Caspase-10 (EC 3.4.22.63, FLICE2, Mch4, CASP-10, ICE-like apoptotic protease 4, apoptotic protease Mch-4, FAS-associated death domain protein interleukin-1beta-converting enzyme 2) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp!Gly
Caspase-10 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-9 (EC 3.4.22.62).
References
- ↑ "Proteases for cell suicide: functions and regulation of caspases". Microbiology and Molecular Biology Reviews 64 (4): 821–46. December 2000. doi:10.1128/mmbr.64.4.821-846.2000. PMID 11104820.
- ↑ "Unique and overlapping substrate specificities of caspase-8 and caspase-10". Oncogene 25 (1): 152–9. January 2006. doi:10.1038/sj.onc.1209015. PMID 16186808.
- ↑ "Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases". European Journal of Immunology 33 (7): 1998–2006. July 2003. doi:10.1002/eji.200324013. PMID 12884866.
- ↑ "Activation of caspases-8 and -10 by FLIP(L)". The Biochemical Journal 382 (Pt 2): 651–7. September 2004. doi:10.1042/bj20040809. PMID 15209560.
External links
- Caspase-10 at the US National Library of Medicine Medical Subject Headings (MeSH)
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