Biology:Carbonic anhydrase 5B, mitochondrial
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Carbonic anhydrase 5B, mitochondrial is an enzyme that in humans is encoded by the CA5B gene.[1][2]
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It has a wider tissue distribution than CA VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles.[2]
References
- ↑ "Human mitochondrial carbonic anhydrase VB. cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome x". J Biol Chem 274 (30): 21228–33. Aug 1999. doi:10.1074/jbc.274.30.21228. PMID 10409679.
- ↑ 2.0 2.1 "Entrez Gene: CA5B carbonic anhydrase VB, mitochondrial". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11238.
External links
- Human CA5B genome location and CA5B gene details page in the UCSC Genome Browser.
Further reading
- "Human carbonic anhydrases and carbonic anhydrase deficiencies". Annu. Rev. Biochem. 64: 375–401. 1995. doi:10.1146/annurev.bi.64.070195.002111. PMID 7574487.
- "Carbonic anhydrase isozymes in the human pancreas". Digestive and Liver Disease 33 (1): 68–74. 2001. doi:10.1016/s1590-8658(01)80138-9. PMID 11303978.
- "Mitochondrial carbonic anhydrase CA VB: Differences in tissue distribution and pattern of evolution from those of CA VA suggest distinct physiological roles". Proc. Natl. Acad. Sci. U.S.A. 97 (4): 1677–82. 2000. doi:10.1073/pnas.97.4.1677. PMID 10677517. Bibcode: 2000PNAS...97.1677S.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. 2004. doi:10.1101/gr.2435604. PMID 15342556.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines". Bioorg. Med. Chem. Lett. 17 (5): 1336–40. 2007. doi:10.1016/j.bmcl.2006.11.075. PMID 17174092.
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