Biology:CKM (gene)

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Creatine kinase, muscle also known as MCK is a creatine kinase that in humans is encoded by the MCK gene.

Structure

In the figure to the right, the crystal structure of the muscle-type M-CK monomer is shown. In vivo, two such monomers arrange symmetrically to form the active MM-CK enzyme.

Function

The protein encoded by this gene is a cytoplasmic enzyme involved in cellular energy homeostasis. The encoded protein reversibly catalyzes the transfer of "energy-rich" phosphate between ATP and creatine and between phospho-creatine and ADP. Its functional entity is a MM-CK homodimer in striated (sarcomeric) skeletal and cardiac muscle.

Clinical significance

In heart, in addition to the MM-CK homodimer, also the heterodimer MB-CK consisting of one muscle (M-CK) and one brain-type (B-CK) subunit is expressed. The latter may be an important serum marker for myocardial infarction, if released from damaged myocardial cells into the blood where it can be detected by clinical chemistry.

Further reading

• "The generation of the oxidized form of creatine kinase is a negative regulation on muscle creatine kinase.". J. Biol. Chem. 282 (16): 12022–9. 2007. doi:10.1074/jbc.M610363200. PMID 17303563. 
• "ACE ID genotype affects blood creatine kinase response to eccentric exercise.". J. Appl. Physiol. 103 (6): 2057–61. 2007. doi:10.1152/japplphysiol.00867.2007. PMID 17885020. 
• "CK-MM autoantibodies: prevalence, immune complexes, and effect on CK clearance.". Muscle Nerve 34 (3): 335–46. 2006. doi:10.1002/mus.20594. PMID 16810680. 
• "Functional aspects of creatine kinase in brain.". Dev. Neurosci. 15 (3–5): 249–60. 1993. doi:10.1159/000111342. PMID 7805577. 
• "Long-term prognostic value of creatine kinase-myocardial band mass after cardiac surgery in low-risk patients with stable angina.". Cardiology 113 (2): 122–31. 2009. doi:10.1159/000177949. PMID 19039220. 
• "World-class performance in lightweight rowing: Is it genetically influenced? A comparison with cyclists, runners and non-athletes.". Br J Sports Med 44 (12): 898–901. 2008. doi:10.1136/bjsm.2008.051680. PMID 18801770. 
• "Creatine and creatinine metabolism.". Physiol. Rev. 80 (3): 1107–213. 2000. doi:10.1152/physrev.2000.80.3.1107. PMID 10893433. 
• "Significance of CK-elevation in noncompaction with regard to cardiac and neuromuscular disease.". Int. J. Cardiol. 130 (2): 174–9. 2008. doi:10.1016/j.ijcard.2007.08.038. PMID 18055044. 
• "The identification of myocilin-associated proteins in the human trabecular meshwork.". Exp. Eye Res. 82 (6): 1046–52. 2006. doi:10.1016/j.exer.2005.09.016. PMID 16289162. 
• "CK-MM and ACE genotypes and physiological prediction of the creatine kinase response to exercise.". J. Appl. Physiol. 103 (2): 504–10. 2007. doi:10.1152/japplphysiol.00081.2007. PMID 17478608. 
• "Cardiovascular disease testing on the Dimension Vista system: biomarkers of acute coronary syndromes.". Clin. Biochem. 42 (13–14): 1444–51. 2009. doi:10.1016/j.clinbiochem.2009.05.020. PMID 19523464. 
• "Exploring the role of the active site cysteine in human muscle creatine kinase.". Biochemistry 45 (38): 11464–72. 2006. doi:10.1021/bi0607002. PMID 16981706. 
• "Duchenne muscular dystrophy and idiopathic hyperCKemia in the same family.". Eur. J. Paediatr. Neurol. 12 (5): 404–7. 2008. doi:10.1016/j.ejpn.2007.10.014. PMID 18833644. 
• "Does the polygenic profile determine the potential for becoming a world-class athlete? Insights from the sport of rowing.". Scand J Med Sci Sports 20 (1): e188–e194. 2009. doi:10.1111/j.1600-0838.2009.00943.x. PMID 19422651. 
• "Muscle-specific creatine kinase gene polymorphism and running economy responses to an 18-week 5000-m training programme.". Br J Sports Med 40 (12): 988–91. 2006. doi:10.1136/bjsm.2006.029744. PMID 17000714. 
• "Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis.". J. Mol. Biol. 376 (5): 1224–36. 2008. doi:10.1016/j.jmb.2007.11.049. PMID 18222470. 
• "Capture of monomeric refolding intermediate of human muscle creatine kinase.". Protein Sci. 15 (1): 171–81. 2006. doi:10.1110/ps.051738406. PMID 16373479. 
• "Changes in serum cartilage oligomeric matrix protein (COMP), plasma CPK and plasma hs-CRP in relation to running distance in a marathon (42.195 km) and an ultra-marathon (200 km) race.". Eur. J. Appl. Physiol. 105 (5): 765–70. 2009. doi:10.1007/s00421-008-0961-x. PMID 19125286. 
• "Creatine kinase in non-muscle tissues and cells.". Mol. Cell. Biochem. 133–134: 193–220. 1994. doi:10.1007/BF01267955. PMID 7808454. 

External links

• Creatine+Kinase,+MM+Form at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CKM genome location and CKM gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: P06732 (Creatine kinase M-type) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.