Biology:Bleomycin hydrolase

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Bleomycin hydrolase is an enzyme that in humans is encoded by the BLMH gene.[1][2][3]

Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution. Its biological function is hydrolysis of the reactive electrophile homocysteine thiolactone.[4] Another of its activities is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily.[3]

Interactions

BLMH has been shown to interact with RPL29,[5] RPL11,[5] UBE2I[6] and Amyloid precursor protein.[7]

References

  1. "Gene characterization, promoter analysis, and chromosomal localization of human bleomycin hydrolase". J Biol Chem 272 (52): 33298–304. January 1998. doi:10.1074/jbc.272.52.33298. PMID 9407121. 
  2. "Genomic structure and genetic mapping of the human neutral cysteine protease bleomycin hydrolase". Cancer Res 57 (19): 4191–5. October 1997. PMID 9331073. 
  3. 3.0 3.1 "Entrez Gene: BLMH bleomycin hydrolase". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=642. 
  4. Jarosław Zimny; Marta Sikora; Andrzej Guranowski; Hieronim Jakubowski (2006). "Protective Mechanisms against Homocysteine Toxicity". The Journal of Biological Chemistry 281 (32): 22485–22492. doi:10.1074/jbc.M603656200. PMID 16769724. http://www.jbc.org/content/281/32/22485.abstract. 
  5. 5.0 5.1 Koldamova, R P; Lefterov I M; DiSabella M T; Almonte C; Watkins S C; Lazo J S (June 1999). "Human bleomycin hydrolase binds ribosomal proteins". Biochemistry (UNITED STATES) 38 (22): 7111–7. doi:10.1021/bi990135l. ISSN 0006-2960. PMID 10353821. 
  6. Koldamova, R P; Lefterov I M; DiSabella M T; Lazo J S (December 1998). "An evolutionarily conserved cysteine protease, human bleomycin hydrolase, binds to the human homologue of ubiquitin-conjugating enzyme 9". Mol. Pharmacol. (UNITED STATES) 54 (6): 954–61. doi:10.1124/mol.54.6.954. ISSN 0026-895X. PMID 9855622. 
  7. Lefterov, I M; Koldamova R P; Lazo J S (September 2000). "Human bleomycin hydrolase regulates the secretion of amyloid precursor protein". FASEB J. (UNITED STATES) 14 (12): 1837–47. doi:10.1096/fj.99-0938com. ISSN 0892-6638. PMID 10973933. 

External links

Further reading