Biology:Benzoate—CoA ligase

From HandWiki
Short description: Class of enzymes
Benzoate—CoA ligase
Identifiers
EC number6.2.1.25
CAS number95329-17-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a benzoate—CoA ligase (EC 6.2.1.25) is an enzyme that catalyzes the chemical reaction

ATP + benzoate + CoA [math]\displaystyle{ \rightleftharpoons }[/math] AMP + diphosphate + benzoyl-CoA

The 3 substrates of this enzyme are ATP, benzoate, and CoA, whereas its 3 products are AMP, diphosphate, and benzoyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is benzoate:CoA ligase (AMP-forming). Other names in common use include benzoate-coenzyme A ligase, benzoyl-coenzyme A synthetase, and benzoyl CoA synthetase (AMP forming). This enzyme participates in benzoate degradation via coa ligation.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2V7B.

References