Biology:Apolipoprotein O
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
| ApoO | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | ApoO | ||||||||
| Pfam | PF09769 | ||||||||
| InterPro | IPR019166 | ||||||||
| |||||||||
Apolipoprotein O also known as protein FAM121B is a protein that in humans is encoded by the APOO gene. APOO is a member of the apolipoprotein family.[1]
The human, apolipoprotein O is a 198 amino acids protein that contains a 23 amino acids long signal peptide. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. Apolipoprotein O is the first chondroitine sulphate chain containing apolipoprotein.[1]
Apolipoproteins are proteins that binds to lipids. Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL.
References
External links
- Human APOO genome location and APOO gene details page in the UCSC Genome Browser.
Further reading
- "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.". Am. J. Hum. Genet. 85 (5): 628–42. 2009. doi:10.1016/j.ajhg.2009.10.014. PMID 19913121.
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