Biology:Aminopyrimidine aminohydrolase
From HandWiki
| Aminopyrimidine aminohydrolase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.5.99.2 | ||||||||
| CAS number | 9024-80-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Aminopyrimidine aminohydrolase (EC 3.5.99.2, thiaminase, thiaminase II, tenA (gene)) is an enzyme with systematic name 4-amino-5-aminomethyl-2-methylpyrimidine aminohydrolase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction
- (1) 4-amino-5-aminomethyl-2-methylpyrimidine + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 4-amino-5-hydroxymethyl-2-methylpyrimidine + ammonia
- (2) thiamine + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole
This enzyme was previously known as thiaminase II.
References
- ↑ "The second type of bacterial thiaminase". The Journal of Vitaminology 1 (1): 1–7. July 1954. doi:10.5925/jnsv1954.1.1. PMID 13243520.
- ↑ "Purification of thiaminase II". J. Gen. Appl. Microbiol. 6: 30–39. 1960. doi:10.2323/jgam.6.30.
- ↑ "Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II". Biochemistry 44 (7): 2319–29. February 2005. doi:10.1021/bi0478648. PMID 15709744.
- ↑ "The 2.35 A structure of the TenA homolog from Pyrococcus furiosus supports an enzymatic function in thiamine metabolism". Acta Crystallographica Section D 61 (Pt 5): 589–98. May 2005. doi:10.1107/S0907444905005147. PMID 15858269. https://lirias.kuleuven.be/handle/123456789/580796.
- ↑ "A new thiamin salvage pathway". Nature Chemical Biology 3 (8): 492–7. August 2007. doi:10.1038/nchembio.2007.13. PMID 17618314.
- ↑ "Mutagenesis studies on TenA: a thiamin salvage enzyme from Bacillus subtilis". Bioorganic Chemistry 36 (1): 29–32. February 2008. doi:10.1016/j.bioorg.2007.10.005. PMID 18054064.
- ↑ "Structure of trifunctional THI20 from yeast". Acta Crystallographica Section D 67 (Pt 9): 784–91. September 2011. doi:10.1107/S0907444911024814. PMID 21904031.
External links
- Aminopyrimidine+aminohydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)
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