Biology:Aldehyde oxidase 1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Aldehyde oxidase 1 is an enzyme that in humans is encoded by the AOX1 gene.[1][2]
Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide.[1]
Clinical significance
Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis.[2]
See also
References
- ↑ 1.0 1.1 "Entrez Gene: aldehyde oxidase 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=316.
- ↑ 2.0 2.1 "Analysis of aldehyde oxidase and xanthine dehydrogenase/oxidase as possible candidate genes for autosomal recessive familial amyotrophic lateral sclerosis". Somat. Cell Mol. Genet. 21 (2): 121–31. March 1995. doi:10.1007/BF02255787. PMID 7570184. https://zenodo.org/record/1232530.
External links
- Human AOX1 genome location and AOX1 gene details page in the UCSC Genome Browser.
Further reading
- "Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.". Biochem. Biophys. Res. Commun. 345 (3): 1022–32. 2006. doi:10.1016/j.bbrc.2006.04.175. PMID 16712791.
- "Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease.". Aliment. Pharmacol. Ther. 30 (4): 375–84. 2009. doi:10.1111/j.1365-2036.2009.04057.x. PMID 19500084.
- "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.". Mol. Med. 16 (7–8): 247–53. 2010. doi:10.2119/molmed.2009.00159. PMID 20379614.
- Sigruener A et al. (2007). "Human aldehyde oxidase 1 interacts with ATP-binding cassette transporter-1 and modulates its activity in hepatocytes.". Horm. Metab. Res. 39 (11): 781–9. doi:10.1055/s-2007-992129. PMID 17992631.
- "Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II.". Biochem. Biophys. Res. Commun. 282 (5): 1194–200. 2001. doi:10.1006/bbrc.2001.4719. PMID 11302742.
- "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Purification and mechanism of human aldehyde oxidase expressed in Escherichia coli.". Drug Metab. Dispos. 37 (12): 2393–8. 2009. doi:10.1124/dmd.109.029520. PMID 19741035.
- Rodrigues AD (1994). "Comparison of levels of aldehyde oxidase with cytochrome P450 activities in human liver in vitro.". Biochem. Pharmacol. 48 (1): 197–200. doi:10.1016/0006-2952(94)90240-2. PMID 8043023.
- "cDNA cloning, characterization, and tissue-specific expression of human xanthine dehydrogenase/xanthine oxidase.". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10690–4. 1993. doi:10.1073/pnas.90.22.10690. PMID 8248161. Bibcode: 1993PNAS...9010690W.
- "The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a beta2-syntrophin/utrophin complex.". Biochem. Biophys. Res. Commun. 293 (2): 759–65. 2002. doi:10.1016/S0006-291X(02)00303-0. PMID 12054535.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.". Nat. Genet. 41 (12): 1345–9. 2009. doi:10.1038/ng.478. PMID 19898482.
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