Biology:Adenosylcobinamide kinase
From HandWiki
Short description: Class of enzymes
| adenosylcobinamide kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.1.156 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an adenosylcobinamide kinase (EC 2.7.1.156) is an enzyme that catalyzes the chemical reaction
- RTP + adenosylcobinamide [math]\displaystyle{ \rightleftharpoons }[/math] adenosylcobinamide phosphate + RDP
Thus, the two substrates of this enzyme are RTP and adenosylcobinamide, whereas its two products are adenosylcobinamide phosphate and RDP.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is RTP:adenosylcobinamide phosphotransferase. Other names in common use include CobU, adenosylcobinamide kinase/adenosylcobinamide-phosphate, guanylyltransferase, and AdoCbi kinase/AdoCbi-phosphate guanylyltransferase. This enzyme participates in porphyrin and chlorophyll metabolism.
References
- "Purification and characterization of the bifunctional CobU enzyme of Salmonella typhimurium LT2. Evidence for a CobU-GMP intermediate". J. Biol. Chem. 270 (40): 23560–9. 1995. doi:10.1074/jbc.270.40.23560. PMID 7559521.
- "Three-dimensional structure of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase from Salmonella typhimurium determined to 2.3 A resolution". Biochemistry 37 (21): 7686–95. 1998. doi:10.1021/bi973178f. PMID 9601028.
- "Three-dimensional structure of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase (CobU) complexed with GMP: evidence for a substrate-induced transferase active site". Biochemistry 38 (40): 12995–3005. 1999. doi:10.1021/bi990910x. PMID 10529169.
- "Analysis of the adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase (CobU) enzyme of Salmonella typhimurium LT2. Identification of residue His-46 as the site of guanylylation". J. Biol. Chem. 275 (36): 27576–86. 2000. doi:10.1074/jbc.M000977200. PMID 10869342.
- "The biosynthesis of adenosylcobalamin (vitamin B12)". Nat. Prod. Rep. 19 (4): 390–412. 2002. doi:10.1039/b108967f. PMID 12195810.
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