Biology:AADAC
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Arylacetamide deacetylase is an enzyme that in humans is encoded by the AADAC gene.[1][2]
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens.[2]
References
- ↑ "Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase.". J Biol Chem 269 (34): 21650–6. Sep 1994. doi:10.1016/S0021-9258(17)31855-0. PMID 8063807.
- ↑ 2.0 2.1 "Entrez Gene: AADAC arylacetamide deacetylase (esterase)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=13.
Further reading
- "Purification and characterization of a human liver arylacetamide deacetylase.". Biochem. Biophys. Res. Commun. 177 (1): 453–9. 1991. doi:10.1016/0006-291X(91)92005-5. PMID 2043131.
- "Radiation hybrid mapping of human arylacetamide deacetylase (AADAC) locus to chromosome 3.". Genomics 44 (2): 248–50. 1997. doi:10.1006/geno.1997.4879. PMID 9299245.
- Ozols J (1998). "Determination of lumenal orientation of microsomal 50-kDa esterase/N-deacetylase.". Biochemistry 37 (28): 10336–44. doi:10.1021/bi9807916. PMID 9665742.
- "Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esterase.". J. Biol. Chem. 274 (20): 14122–9. 1999. doi:10.1074/jbc.274.20.14122. PMID 10318829.
- "Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation.". J. Biol. Chem. 276 (43): 39522–32. 2001. doi:10.1074/jbc.M101764200. PMID 11481320.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population.". J. Hum. Genet. 48 (5): 249–70. 2003. doi:10.1007/s10038-003-0021-7. PMID 12721789.
- "Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase.". J. Biol. Chem. 279 (30): 31131–8. 2004. doi:10.1074/jbc.M313666200. PMID 15152005.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
External links
- AADAC human gene location in the UCSC Genome Browser.
- AADAC human gene details in the UCSC Genome Browser.
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