Biology:6-Hydroxypseudooxynicotine dehydrogenase
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Short description: Class of enzymes
| 6-hydroxypseudooxynicotine dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.5.99.14 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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6-hydroxypseudooxynicotine dehydrogenase (EC 1.5.99.14) is an enzyme with systematic name 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one:acceptor 6-oxidoreductase (hydroxylating).[1][2][3] This enzyme catalyses the following chemical reaction:
- 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + acceptor + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + reduced acceptor
This enzyme contains a cytidylyl molybdenum cofactor.
References
- ↑ "Nicotine dehydrogenase from Arthrobacter oxidans: A molybdenum-containing hydroxylase". FEMS Microbiology Letters 52: 13–18. 1988. doi:10.1111/j.1574-6968.1988.tb02564.x.
- ↑ "Structural analysis and molybdenum-dependent expression of the pAO1-encoded nicotine dehydrogenase genes of Arthrobacter nicotinovorans". Molecular Microbiology 13 (5): 929–36. September 1994. doi:10.1111/j.1365-2958.1994.tb00484.x. PMID 7815950.
- ↑ "A functional mobA gene for molybdopterin cytosine dinucleotide cofactor biosynthesis is required for activity and holoenzyme assembly of the heterotrimeric nicotine dehydrogenases of Arthrobacter nicotinovorans". Applied and Environmental Microbiology 72 (7): 5126–31. July 2006. doi:10.1128/AEM.00437-06. PMID 16820521.
External links
- 6-hydroxypseudooxynicotine+dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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