Biology:6-Hydroxy-3-succinoylpyridine 3-monooxygenase
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Short description: Class of enzymes
| 6-hydroxy-3-succinoylpyridine 3-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.163 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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6-hydroxy-3-succinoylpyridine 3-monooxygenase (EC 1.14.13.163, 6-hydroxy-3-succinoylpyridine hydroxylase, hspA (gene), hspB (gene)) is an enzyme with systematic name 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate,NADH:oxygen oxidoreductase (3-hydroxylating, succinate semialdehyde releasing).[1][2] This enzyme catalyses the following chemical reaction
- 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2 [math]\displaystyle{ \rightleftharpoons }[/math] 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O
6-hydroxy-3-succinoylpyridine 3-monooxygenase catalyses a reaction in the nicotine degradation pathway of Pseudomonas species.
References
- ↑ "A novel gene, encoding 6-hydroxy-3-succinoylpyridine hydroxylase, involved in nicotine degradation by Pseudomonas putida strain S16". Applied and Environmental Microbiology 74 (5): 1567–74. March 2008. doi:10.1128/AEM.02529-07. PMID 18203859. Bibcode: 2008ApEnM..74.1567T.
- ↑ "A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida". The Journal of Biological Chemistry 286 (45): 39179–87. November 2011. doi:10.1074/jbc.M111.283929. PMID 21949128.
External links
- 6-hydroxy-3-succinoylpyridine+3-monooxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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