Biology:6'''-Hydroxyneomycin C oxidase

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Short description: Class of enzymes
6'''-hydroxyneomycin C oxidase
Identifiers
EC number1.1.3.44
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

6'''-hydroxyneomycin C oxidase (EC 1.1.3.44, neoG (gene)) is an enzyme with systematic name 6'''-deamino-6'''-hydroxyneomycin C:oxygen 6'''-oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

6'''-deamino-6'''-hydroxyneomycin C + O2 [math]\displaystyle{ \rightleftharpoons }[/math] 6'''-deamino-6'''-oxoneomycin C + H2O2

This enzyme participates in biosynthesis of aminoglycoside antibiotics of the neomycin family.

References

  1. "Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin". ChemBioChem 8 (3): 283–8. February 2007. doi:10.1002/cbic.200600371. PMID 17206729. 
  2. "The oxidoreductases LivQ and NeoQ are responsible for the different 6'-modifications in the aminoglycosides lividomycin and neomycin". Journal of Applied Microbiology 111 (3): 642–51. September 2011. doi:10.1111/j.1365-2672.2011.05082.x. PMID 21689223. 

External links