Biology:4a-hydroxytetrahydrobiopterin dehydratase

From HandWiki
Short description: Enzyme
4a-hydroxytetrahydrobiopterin dehydratase
Identifiers
EC number4.2.1.96
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The enzyme 4a-hydroxytetrahydrobiopterin dehydratase (EC 4.2.1.96) catalyzes the chemical reaction

4a-hydroxytetrahydrobiopterin [math]\displaystyle{ \rightleftharpoons }[/math] 6,7-dihydrobiopterin + H2O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 4a-hydroxytetrahydrobiopterin hydro-lyase (6,7-dihydrobiopterin-forming). Other names in common use include 4a-hydroxy-tetrahydropterin dehydratase, pterin-4α-carbinolamine dehydratase, and 4a-hydroxytetrahydrobiopterin hydro-lyase.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1DCO, 1DCP, and 1RU0.

References

  • "Phenylalanine hydroxylase-stimulating protein/pterin-4 alpha-carbinolamine dehydratase from rat and human liver Purification, characterization, and complete amino acid sequence". J. Biol. Chem. 268 (7): 4828–31. 1993. PMID 8444860.