Biology:3-ethylmalate synthase

From HandWiki
Short description: Class of enzymes
3-ethylmalate synthase
Identifiers
EC number2.3.3.7
CAS number9024-01-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a 3-ethylmalate synthase (EC 2.3.3.7) is an enzyme that catalyzes the chemical reaction

butanoyl-CoA + H2O + glyoxylate [math]\displaystyle{ \rightleftharpoons }[/math] 3-ethylmalate + CoA

The 3 substrates of this enzyme are butanoyl-CoA, H2O, and glyoxylate, whereas its two products are 3-ethylmalate and CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is butanoyl-CoA:glyoxylate C-butanoyltransferase (thioester-hydrolysing, 1-carboxypropyl-forming). Other names in common use include 2-ethyl-3-hydroxybutanedioate synthase, and 3-ethylmalate glyoxylate-lyase (CoA-butanoylating). This enzyme participates in glyoxylate and dicarboxylate metabolism.

References