Biology:2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase
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Short description: Class of enzymes
| 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.1.40 | ||||||||
| CAS number | 104645-83-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase (EC 1.3.1.40) is an enzyme that catalyzes the chemical reaction
- 2,6-dioxo-6-phenylhexanoate + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + NADPH + H+
Thus, the two substrates of this enzyme are 2,6-dioxo-6-phenylhexanoate and NADP+, whereas its 3 products are 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2,6-dioxo-6-phenylhexanoate:NADP+ Delta2-oxidoreductase. Other names in common use include 2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide, and adenine dinucleotide phosphate) reductase.
References
- "Purification and some properties of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid(HOPDA) reducing enzyme from Pseudomonas cruciviae S93B1 involved in the degradation of biphenyl". Agric. Biol. Chem. 50 (6): 1513–1518. 1986. doi:10.1271/bbb1961.50.1513.
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