Biology:2-acylglycerol O-acyltransferase

From HandWiki
Short description: Class of enzymes
2-acylglycerol O-acyltransferase
Identifiers
EC number2.3.1.22
CAS number9055-17-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a 2-acylglycerol O-acyltransferase (EC 2.3.1.22) is an enzyme that catalyzes the chemical reaction

acyl-CoA + 2-acylglycerol [math]\displaystyle{ \rightleftharpoons }[/math] CoA + diacylglycerol

Thus, the two substrates of this enzyme are acyl-CoA and 2-acylglycerol, whereas its two products are CoA and diacylglycerol.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:2-acylglycerol O-acyltransferase. Other names in common use include acylglycerol palmitoyltransferase, monoglyceride acyltransferase, acyl coenzyme A-monoglyceride acyltransferase, and monoacylglycerol acyltransferase. This enzyme participates in glycerolipid metabolism.

References

  • "Purification and preliminary characterization of 2-monoacylglycerol acyltransferase from rat intestinal villus cells". Can. J. Biochem. Cell Biol. 63 (5): 341–7. 1985. doi:10.1139/o85-050. PMID 4016575.