Biology:16-alpha-hydroxysteroid dehydrogenase
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Short description: Class of enzymes
| 16-alpha-hydroxysteroid dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.147 | ||||||||
| CAS number | 37250-74-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 16alpha-hydroxysteroid dehydrogenase (EC 1.1.1.147) is an enzyme that catalyzes the chemical reaction
- a 16alpha-hydroxysteroid + NAD(P)+ [math]\displaystyle{ \rightleftharpoons }[/math] a 16-oxosteroid + NAD(P)H + H+
The 3 substrates of this enzyme are 16alpha-hydroxysteroid, NAD+, and NADP+, whereas its 4 products are 16-oxosteroid, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 16alpha-hydroxysteroid:NAD(P)+ 16-oxidoreductase. This enzyme is also called 16alpha-hydroxy steroid dehydrogenase.
References
- "16-alpha-hydroxysteroid dehydrogenase of rat kidney. Purification, assay, and properties". J. Biol. Chem. 241 (17): 4011–5. 1966. PMID 4380686.
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