Biology:1,5-anhydro-D-fructose dehydratase

From HandWiki
Short description: Class of enzymes
1,5-anhydro-D-fructose dehydratase
Identifiers
EC number4.2.1.111
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme 1,5-anhydro-D-fructose dehydratase (EC 4.2.1.111) catalyzes the chemical reaction

1,5-anhydro-D-fructose [math]\displaystyle{ \rightleftharpoons }[/math] 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O

It catalyzes two steps in the anhydrofructose pathway process.[1]

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 1,5-anhydro-D-fructose hydro-lyase (ascopyrone-M-forming). Other names in common use include 1,5-anhydro-D-fructose 4-dehydratase, 1,5-anhydro-D-fructose hydrolyase, 1,5-anhydro-D-arabino-hex-2-ulose dehydratase, AFDH, AF dehydratase, and 1,5-anhydro-D-fructose hydro-lyase.

References

  • "Enzymatic description of the anhydrofructose pathway of glycogen degradation; I. Identification and purification of anhydrofructose dehydratase, ascopyrone tautomerase and alpha-1,4-glucan lyase in the fungus Anthracobia melaloma". Biochim. Biophys. Acta 1672 (2): 120–9. 2004. doi:10.1016/j.bbagen.2004.03.004. PMID 15110094. 
  • "The anhydrofructose pathway and its possible role in stress response and signaling". Biochim. Biophys. Acta 1760 (9): 1314–22. 2006. doi:10.1016/j.bbagen.2006.05.007. PMID 16822618. 
  • Yu S (2005). "Enzymatic description of the anhydrofructose pathway of glycogen degradation II. Gene identification and characterization of the reactions catalyzed by aldos-2-ulose dehydratase that converts 1,5-anhydro-D-fructose to microthecin with ascopyrone M as the intermediate". Biochim. Biophys. Acta 1723 (1–3): 63–73. doi:10.1016/j.bbagen.2005.01.004. PMID 15716041. 

See also