Biology:(S)-2-hydroxy-fatty-acid dehydrogenase

From HandWiki
Short description: Class of enzymes
(S)-2-hydroxy-fatty-acid dehydrogenase
Identifiers
EC number1.1.1.99
CAS number37250-33-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a (S)-2-hydroxy-fatty-acid dehydrogenase (EC 1.1.1.99) is an enzyme that catalyzes the chemical reaction

(S)-2-hydroxystearate + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] 2-oxostearate + NADH + H+

Thus, the two substrates of this enzyme are (S)-2-hydroxystearate and NAD+, whereas its 3 products are 2-oxostearate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-2-hydroxystearate:NAD+ oxidoreductase. Other names in common use include dehydrogenase, L-2-hydroxy fatty acid, L-2-hydroxy fatty acid dehydrogenase, and 2-hydroxy fatty acid oxidase.

References

  • "Carboxyl-terminal sequence of human gastricsin and pepsin". J. Biol. Chem. 245 (9): 2189–93. 1970. PMID 4909888.