Biology:(R)-2-methylmalate dehydratase

From HandWiki
Short description: Class of enzymes
(R)-2-methylmalate dehydratase
Identifiers
EC number4.2.1.35
CAS number9027-92-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The enzyme(R)-2-methylmalate dehydratase (EC 4.2.1.35) catalyzes the chemical reaction

(R)-2-methylmalate [math]\displaystyle{ \rightleftharpoons }[/math] 2-methylmaleate + H2O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (R)-2-methylmalate hydro-lyase (2-methylmaleate-forming). Other names in common use include citraconate hydratase, citraconase, citramalate hydro-lyase, (−)-citramalate hydro-lyase, and (R)-2-methylmalate hydro-lyase. This enzyme participates in valine, leucine and isoleucine biosynthesis and c5-branched dibasic acid metabolism. It employs one cofactor, iron.

References

  • "Purification and properties of citraconase". J. Biol. Chem. 243 (9): 2367–72. 1968. PMID 4296839.