Chemistry:Talfirastide

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Talfirastide (development name TXA127) is an experimental synthetic analog of angiotensin (1-7)[1] that works as an angiotensin II type 1 receptor–biased ligand. It has been tested in people with COVID-19[2] and stroke.[3]

References

  1. ↑ Wagener, Gebhard; Goldklang, Monica P. et al. (28 July 2022). "A randomized, placebo-controlled, double-blinded pilot study of angiotensin 1–7 (TXA-127) for the treatment of severe COVID-19". Critical Care 26 (1): 229. doi:10.1186/s13054-022-04096-9. ISSN 1364-8535. PMID 35902867. 
  2. ↑ Self, Wesley H.; Shotwell, Matthew S. et al. (11 April 2023). "Renin-Angiotensin System Modulation With Synthetic Angiotensin (1-7) and Angiotensin II Type 1 Receptor–Biased Ligand in Adults With COVID-19: Two Randomized Clinical Trials". JAMA 329 (14): 1170–1182. doi:10.1001/jama.2023.3546. PMID 37039791. 
  3. ↑ "Phase 2 Study of TXA127 in Post-ischemic Stroke Patients - Full Text View - ClinicalTrials.gov" (in en). https://classic.clinicaltrials.gov/ct2/show/NCT06135103. 



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