View source for Biology:Tricetin 3',4',5'-O-trimethyltransferase

{{Infobox enzyme
| Name       = Tricetin 3',4',5'-O-trimethyltransferase
| EC_number  = 2.1.1.169
| CAS_number =
| GO_code    = 
| image      = 
| width      = 
| caption    =  
}}
'''Tricetin 3',4',5'-O-trimethyltransferase''' ({{EC number|2.1.1.169}}, ''FOMT'', ''TaOMT1'', ''TaCOMT1'', ''TaOMT2'') is an [[Biology:Enzyme|enzyme]] with [[Biology:List of enzymes|systematic name]] ''S-adenosyl-L-methionine:tricetin 3',4',5'-O-trimethyltransferase''.<ref>{{cite journal | vauthors = Kornblatt JA, Zhou JM, Ibrahim RK | title = Structure-activity relationships of wheat flavone O-methyltransferase: a homodimer of convenience | journal = The FEBS Journal | volume = 275 | issue = 9 | pages = 2255–66 | date = May 2008 | pmid = 18397325 | doi = 10.1111/j.1742-4658.2008.06377.x | doi-access = free }}</ref><ref>{{cite journal | vauthors = Zhou JM, Gold ND, Martin VJ, Wollenweber E, Ibrahim RK | title = Sequential O-methylation of tricetin by a single gene product in wheat | journal = Biochimica et Biophysica Acta (BBA) - General Subjects | volume = 1760 | issue = 7 | pages = 1115–24 | date = July 2006 | pmid = 16730127 | doi = 10.1016/j.bbagen.2006.02.008 }}</ref><ref>{{cite journal | vauthors = Zhou JM, Seo YW, Ibrahim RK | title = Biochemical characterization of a putative wheat caffeic acid O-methyltransferase | journal = Plant Physiology and Biochemistry | volume = 47 | issue = 4 | pages = 322–6 | date = April 2009 | pmid = 19211254 | doi = 10.1016/j.plaphy.2008.11.011 }}</ref> This enzyme [[Chemistry:Catalysis|catalyses]] the following [[Chemistry:Chemical reaction|chemical reaction]]

: 3 S-adenosyl-L-methionine + [[Chemistry:Tricetin|tricetin]] <math>\rightleftharpoons</math> 3 S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin (overall reaction)
:(1a) S-adenosyl-L-methionine + tricetin <math>\rightleftharpoons</math> S-adenosyl-L-homocysteine + 3'-O-methyltricetin
:(1b) S-adenosyl-L-methionine + 3'-O-methyltricetin <math>\rightleftharpoons</math> S-adenosyl-L-homocysteine + 3',5'-O-dimethyltricetin
:(1c) S-adenosyl-L-methionine + 3',5'-O-dimethyltricetin <math>\rightleftharpoons</math> S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin

The enzyme from ''[[Biology:Triticum aestivum|Triticum aestivum]]'' catalyses the sequential O-methylation of [[Chemistry:Tricetin|tricetin]] via 3'-O-methyltricetin, 3',5'-O-methyltricetin to 3',4',5'-O-trimethyltricetin.

== References ==
{{reflist}}

== External links ==
* {{MeshName|Tricetin+3',4',5'-O-trimethyltransferase}}

{{One carbon transferases}}
{{Enzymes}}

[[Category:EC 2.1.1]]

{{Sourceattribution|Tricetin 3',4',5'-O-trimethyltransferase}}