Template:Affinities of a selection of androgen receptor ligands at steroid hormone receptors
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| Compound | AR | ER | PR | GR | MR |
|---|---|---|---|---|---|
| Metribolone | 290 | < 0.1 | 190 | 4 | 38 |
| Dihydrotestosterone | 180 | ? | ? | ? | ? |
| Testosterone | 100 | ? | ? | ? | ? |
| Cyproterone acetate | 10 | ? | ? | ? | ? |
| Bicalutamide | 1.8 | ? | ? | ? | ? |
| Nilutamide | 0.8 | ? | ? | ? | ? |
| Hydroxyflutamide | 0.8 | ? | ? | ? | ? |
| RU-59063 | 300 | <0.1 | <0.1 | <0.1 | <0.1 |
| RU-58841 | 150 | ? | ? | ? | ? |
| RU-58642 | 46 | <0.1 | <0.1 | <0.1 | <0.1 |
| RU-57073 | 163 | <0.1 | <0.1 | <0.1 | <0.1 |
| RU-56187 | 92 | <0.1 | <0.1 | <0.1 | <0.1 |
| Notes: Values are RBAs (%). Reference ligands (100%) were testosterone for the AR, estradiol for the ERα and ERβ, progesterone for the PR, dexamethasone for the GR, and aldosterone for the MR. Sources: [1][2][3] | |||||
References
- ↑ "Non-steroidal antiandrogens: synthesis and biological profile of high-affinity ligands for the androgen receptor". The Journal of Steroid Biochemistry and Molecular Biology 48 (1): 111–9. January 1994. doi:10.1016/0960-0760(94)90257-7. PMID 8136296.
- ↑ "RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism". J. Steroid Biochem. Mol. Biol. 48 (1): 55–60. January 1994. doi:10.1016/0960-0760(94)90250-X. PMID 8136306.
- ↑ "Pharmacological profile of RU 58642, a potent systemic antiandrogen for the treatment of androgen-dependent disorders". J. Steroid Biochem. Mol. Biol. 64 (1-2): 103–11. January 1998. doi:10.1016/S0960-0760(97)00151-9. PMID 9569015.
